The Influence of Age on Dexmedetomidine Pharmacodynamic
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
Dexmedetomidine(DEX) is a novel , highly selective α2 adrenergic receptor agonists , and its
selectivity for α2 receptor is 1600 times higher than α1.It also could provide dose-dependent
sedation , analgesia , anti-anxiety and inhibition of sympathetic nerves and other effects
.At earlier time It was approved by the FDA only for short-time sedation during mechanical
ventilation of adult patients (<24h) in ICU. Because of its minimal impact on the respiratory
, currently it was more and more widely used to sedate patients undergoing regional
anesthesia.Many anesthetic pharmacokinetics and pharmacodynamics are often affected by age
and gender,such as the drug sensitivity of propofol and remifentanil is increased with
age,while the current study also demonstrated that gender may influence the sedate efficacy
of propofol and the sensitivity of muscle loose of rocuronium. Current studies with regard to
the effects of age and gender on dexmedetomidine pharmacodynamic are rare. The study is aim
to explore the right DEX dose of different Age of patients to produce suitable
sedation.Dexmedetomidine be used in patients with combined spinal and epidural anesthesia for
sedation,which is monitored by the BIS,during the operation.The relation between BIS values
and the depth of sedation for patients is also investigated.
Phase:
Phase 4
Details
Lead Sponsor:
Guangzhou General Hospital of Guangzhou Military Command