The Impact of Venlafaxine on Apnea Hypopnea Index in Obstructive Sleep Apnea
Status:
Completed
Trial end date:
2016-07-01
Target enrollment:
Participant gender:
Summary
The investigators hypothesis is that obstructive sleep apnea (OSA) patients with a low
arousal threshold may wake up too early during a respiratory event, before upper airway
muscles can be activated to achieve stable ventilation. Thus, strategies to manipulate the
respiratory arousal threshold could potentially improve the quality of sleep and sleep
disordered breathing. Agents that raise arousal threshold are therefore likely to benefit
some patients with OSA. The overall goal of this project is to determine the importance of
the arousal threshold in OSA, determine which patients might benefit from a raised arousal
threshold, and test this hypothesis by using pharmacological manipulation of the arousal
threshold to achieve this goal.