The Impact of TORasemide oN hemodynAmic and Neurohormonal Stress, and carDiac remOdeling in Heart Failure
Status:
Unknown status
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
The aim of the study is to compare the effects of torasemide and furosemide on clinical and
biochemical parameters of hemodynamic and neurohormonal compensation and myocardial
remodeling in patients with chronic heart failure with indications for use of loop diuretics.
The study protocol 100 patients with heart failure NYHA (New York Heart Association) II-IV
(stable or exacerbation aligned cardiopulmonary at the time of enrollment, with a fixed-dose
loop diuretics]) treated with optimal medical therapy as clinically indicated for use loop
diuretics. Patients will be randomized to treatment with furosemide and torasemide
(randomization 1 : 1). After randomization, furosemide will continue in its current
fixed-dose or will be replaced by equipotential dose of torasemide (4:1). The minimal
follow-up of patients in the study will be at least six months.