The Impact of Nebivolol Versus Metoprolol on Quality of Life
Status:
Terminated
Trial end date:
2013-07-01
Target enrollment:
Participant gender:
Summary
In an open label analysis, nebivolol has been shown to have a positive impact on quality of
life in the general hypertensive population. That is, patients treated with nebivolol
reported less side effects compared to those treated with metoprolol. Also, more nebivolol
treated patients reached normalization of blood pressure. Although there is no data, it is
believed that the impact would be similar in renal transplant recipients.
The primary goal of this study is to determine if nebivolol will improve the quality of life
measurements of kidney transplant recipients as compared to those treated with metoprolol
succinate. This will be measured by comparing the scores of four quality of life
questionnaires taken before and after 12 weeks of treatment with study drug. Other aims of
this study are to determine if the use of nebivolol is cost-effective in the renal transplant
recipient; determine if there is a change in urine protein excretion and renal function with
the use of nebivolol; and determine the number of patients that maintain or achieve a target
blood pressure of ≤ 120/80 mmHg.