The Impact of NBP on the Collateral Circulation in ICA/M1 Occlusion
Status:
Completed
Trial end date:
2019-12-30
Target enrollment:
Participant gender:
Summary
Stroke is the first leading cause of death in China, and is responsible for almost 22.4% of
deaths. In approximately 80% of cases stroke is ischaemic, i.e. caused by disruption of blood
flow to part of the brain from an acute arterial occlusion. Survival of penumbral tissue
distal to an arterial occlusion depends on collateral circulation via the Circle of Willis
and leptomeningeal anastomises. Collateral flow is dynamic and failure is associated with
infarct growth. The presence of adequate collaterals has been shown to be associated with
age, history of statin use, and non-hypertension. Dl-3-n-butylphthalide (NBP), isolated from
the seeds of celery, and found to exert protective effects against ischemic brain and
increase leptomeningeal blood flow. This study investigate whether NBP injection prescribed
during acute stroke will have a significant effect to improve collateral circulation in
patients of anterior circulation occlusion.
Phase:
Phase 4
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University