The Impact of Ketamine on the Reward Circuitry of Suicidal Patients
Status:
Withdrawn
Trial end date:
2017-02-28
Target enrollment:
Participant gender:
Summary
Every 40 seconds, someone in the world dies by suicide. There is a lack of effective and safe
antisuicidal agents for preventing suicide attempts. This leads to the immense worldwide
individual, financial, and societal burden of suicide-which is projected to rise in the
coming decades-supporting the need for antisuicidal treatments.
This treatment gap may be filled through understanding the neurobiology of suicide, which can
guide the development of targeted antisuicidal treatments. Though some research has examined
the neurobiology of suicidal ideation in the context of depression-implicating the orbital
frontal cortex, anterior cingulate cortex, and striatum-the underlying pathophysiology and
neurobiology of suicidal ideation as a separate construct from depression remains largely
unknown. Therefore, the investigators propose to study the neurocircuitry of suicidal
thoughts, regardless of whether or not depression is present.