The Impact of Intravenous Anaesthesia on Angiogenesis in Patients With Breast Cancer (TIVA/TCI-BC)
Status:
Completed
Trial end date:
2019-09-01
Target enrollment:
Participant gender:
Summary
Because neoplastic disease is one of the leading causes of death worldwide and breast cancer
is one of the most frequent neoplasia among women, the possibility of influencing the
evolution of patients starting from the moment of surgical intervention using a
perianesthesic intervention is a scientific topic of high interest. The study will compare
two anesthetic techniques and their efficiency in lowering the factors that can favorize the
dissemination of neoplasia and their role in the prevention of postoperative pain. The serum
level of vascular endothelial growth factor A (VEGF-A) will be determined before and after
the surgical intervention after using two different types of anesthesia (inhalational and
intravenous), and the immunohistochemical expression of vascular endothelial growth factor
receptors (VEGFR) will be determined on the excised tissue. For the two different types of
anesthesia a continuous infusion of lidocaine 1% will be associated. The study will compare
the short-term and long term-outcome of the patients assigned the two different types of
anesthesia and their immediate postoperative evolution .
Phase:
Phase 2
Details
Lead Sponsor:
Iuliu Hatieganu University of Medicine and Pharmacy