The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes
Status:
Completed
Trial end date:
2019-05-22
Target enrollment:
Participant gender:
Summary
In this protocol, 60 subjects with DM1 will be studied at baseline, after 12 weeks of MCR
blockade or 12 weeks of exercise, and again after an additional 12 weeks of MCR blockade,
exercise or the combination of both interventions. The investigators will assess function in
conduit (pulse wave velocity-PWV, flow-mediated dilation-FMD and augmentation index-AI),
resistance (post-ischemic flow velocity-PIFV) and heart and skeletal muscle microvascular
(contrast enhanced ultrasound-CEU) vessels before and after 2 hrs of a euglycemic insulin
clamp.
We hypothesize that compared to healthy controls, both baseline and insulin-responsive
vascular function are impaired throughout the arterial vasculature by DM1 and that exercise
training and/or mineralocorticoid receptor (MCR) blockade will improve both baseline and
insulin-responsive pan-arterial function.
Phase:
N/A
Details
Lead Sponsor:
University of Virginia
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)