The Impact of Different Anticoagulant Therapy on Hemorrhage and Coagulation After Thoracic Surgery

• Status: Completed
• Trial end date: 2013-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether the use of different dose of LMWH compared with fondaparinux for thromboprophylaxis is efficacious and safety after thoracic surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shanghai Zhongshan Hospital
• Treatments: Anticoagulants; Calcium; Calcium, Dietary; Fondaparinux; Nadroparin; PENTA

Criteria

Inclusion Criteria:

• clinical diagnosis of esophageal carcinoma and planned for esophagectomy

• clinical diagnosis of lung carcinoma and planned for lung resection

• general anesthesia combined with epidural anesthesia

Exclusion Criteria:

• blood clotting disfunction before surgery

• anticoagulating or antiplatelet history before surgery

• low blood platelets count

• hemorrhagic disease

• cerebral hemorrhage

• cerebral,spinal,ophthalmologic operation history

• peptic ulcer

• bleeding>400ml in operation

• bleeding>100ml/h after operation

• blood transfusion in or after operation

• severe renal or liver disfunction

• severe hypertension