The High Density Lipoprotein and Endothelial Function, Niacin and Nitric Oxide Study (The High-Ennd Study)
Status:
Completed
Trial end date:
2007-07-01
Target enrollment:
Participant gender:
Summary
The aim of the present study is to characterize novel mechanisms whereby HDL may exert potent
vasculoprotective effects independent of reverse cholesterol transport, in particular the
effect of HDL on the regulation of the vascular NAD(P)H oxidase enzyme system, a major
vascular source of superoxide, known to be important for endothelial dysfunction. In
addition, the present study will characterize the effect of HDL on endothelial progenitor
cell (EPC) mobilization, nitric oxide production and in vivo regenerative capacity.