The HOLIDAY (HOw ALcohol InDuces Atrial TachYarrhythmias) Study
Status:
Completed
Trial end date:
2020-05-01
Target enrollment:
Participant gender:
Summary
Atrial fibrillation (AF) is the most common sustained arrhythmia in the United States and it
has been associated with ethanol use. Understanding how ethanol affects the electrical
properties of the heart and induces AF has important public health implications. The
objective of this research is to investigate the mechanistic relationship between ethanol and
atrial fibrillation in humans by performing a placebo controlled study looking at the
electrical properties of the heart in patients receiving intravenous ethanol or placebo. The
investigators hypothesize that ethanol increases the susceptibility of human myocardium to
atrial fibrillation through electrophysiologic changes in the atrial myocardium in the acute
setting.
Phase:
N/A
Details
Lead Sponsor:
University of California, San Francisco
Collaborator:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)