The Gut Microbiome in Women With Polycystic Ovary Syndrome
Status:
Completed
Trial end date:
2020-07-03
Target enrollment:
Participant gender:
Summary
Testing two different strategies for weight loss intervention and revealing possible changes
in composition of gut microbiota, in order to provide more insight in the effect of dietary
changes and weight loss treatments on gut microbiome in overweight and obese women with
polycystic ovary syndrome (PCOS). The two strategies are:
- dietary advice plus myo-inositol and folic acid
- dietary advice plus liraglutide, glucagon-like peptide-1 (GLP-1) receptor agonist
Primary outcome will be weight loss. Secondary outcomes are longitudinal changes in
clinical features associated with PCOS and metabolic syndrome, longitudinal changes in
gut microbiome with interventions.
Subjects will be treated during 16 weeks and follow-up will take 16 weeks after stop of
treatment.