The Electroencephalogram and Clinical Effect of Ketamine
Status:
Terminated
Trial end date:
2020-09-01
Target enrollment:
Participant gender:
Summary
The electroencephalography (EEG) is a noninvasive medical technique for monitoring and
recording the electrical activity of brain. The Hilbert-Huang Transformation (HHT) was
proposed to decompose EEG signal into intrinsic mode functions (IMF). HHT can obtain
instantaneous frequency data and work well for nonstationary and nonlinear data. We applied
this method in perioperative EEG signal analysis in order to find the energy shift and
quantify the energy change during general anesthesia. Ketamine was a depolarized sedative
which was wildly used in anesthesia. We are trying to find the energy change after ketamine
injection, and the interaction between different oscillations in EEG. The whole brain mapping
for ketamine and other sedatives interaction is the next step.