The Efficacy of Symbiotic on Cytokines

• Status: Completed
• Trial end date: 2013-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this prospective double blinded randomised study is to investigate the efficacy of symbiotic preparation which contains lactobacillus casei, L. rhamnosus, L. plantarum, Bifidobacterium lactis, fructo and galactooligosaccharide on cytokines as interferon-gama acting on Th1 pathway, interleukin -5 acting on Th2, interleukin -10 acting on T regulatory pathway, and interleukin -17 acting on Th-17 pathway that were related with necrotizing enterocolitis pathogenesis in very low birth weight neonates.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Zeynep Kamil Maternity and Pediatric Research and Training Hospital

Criteria

Inclusion Criteria:

1. Neonates born 26- 32 gestational weeks and 750-1500 gram birth weights

2. Neonates who tolerated minimal enteral feeding during first week of life

Exclusion Criteria:

1. PROM> 24 hour and/or chorioamnionitis

2. Mechanical ventilation supply more than 7 days

3. Culture proven sepsis

4. Major congenital anomaly

5. Neonates undergoing surgery