The Efficacy of Red Grape Seed Extract on Lipid Profile and Oxidized Low-Density Lipoprotein (OX-LDL)
Status:
Completed
Trial end date:
2009-02-01
Target enrollment:
Participant gender:
Summary
Antioxidants are potent scavengers of free radicals and serve as inhibitors of neoplastic
processes. A large number of synthetic and natural antioxidants are known to induce
beneficial effects on human health and disease prevention. Cardioprotective ability of grape
seed extract polyphenols (GSEP) was studied in animals and humans. It has been suggested that
grape seed proanthocyanidins have cardioprotective effects against reperfusion-induced injury
of free radicals after ischemia. In another study, it is suggested that proanthocyanidins,
the major polyphenols in red wine, might trap reactive oxygen species in aqueous series such
as plasma and interstitial fluid of the arterial wall; thereby inhibiting oxidation of
low-density lipoprotein (LDL) and showing an antiatherosclerotic activity. The only human
model study designed to evaluate the effect of a standardized formulation of a GSEP
(leucoselect-phytosome [LP]) on the susceptibility of LDL to oxidation in a group of heavy
smokers, revealed that the antioxidant potential of GSEP may be effective in oxidative stress
(smoking); however more investigational data are needed before wider use in clinical
settings. Based on these observations, the investigators decided to evaluate the effect of
GSEP in reducing OX-LDL in patients diagnosed with mild hyperlipidemia.