Overview

The Efficacy of Prednisone and Combination Therapy With Methylprednisolone and Cyclophosphamide on IMN in Stage I.

Status:
Unknown status
Trial end date:
2019-06-30
Target enrollment:
0
Participant gender:
All
Summary
Multi-center, prospective, randomized, controlled study to verify the efficacy of prednisone alone and combination therapy with methylprednisolone and cyclophosphamide in the treatment of stage I membranous nephropathy.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Wenhu Liu
Treatments:
Cyclophosphamide
Glucocorticoids
Immunosuppressive Agents
Methylprednisolone
Methylprednisolone acetate
Methylprednisolone Hemisuccinate
Prednisolone
Prednisolone acetate
Prednisolone hemisuccinate
Prednisolone phosphate
Prednisone
Criteria
Inclusion Criteria:

1. The pathological examination of renal biopsy was consistent with the early idiopathic
membranous nephropathy

2. Meeting one of the following three condition:

- Urine protein quantitation >4g/d,or 50% higher than baseline,RASS blocker treat
for 6 months without trend of decrease ②Serious or disabling complications
related to nephrotic syndrome ③In the 6-12 months after diagnosis of idiopathic
membranous nephropathy, serum creatinine increased by more than 30%, while eGFR
eGFR≥25ml/min/1.73m2.And excludeing other causes of renal dysfunction

Exclusion Criteria:

1. Secondary membranous nephropathy

2. Serious complications

3. Considering the effect of cyclophosphamide on the of function of sex gland,all
patients with childbearing age or fertility requirement cannot participate in this
study