The Efficacy of Mutaflor(E. Coli Nissle 1917, Mutaflor®) for Chronic Constipation:Multicenter Study
Status:
Completed
Trial end date:
2017-10-01
Target enrollment:
Participant gender:
Summary
Chronic constipation is a prevalent, burdensome gastrointestinal disorder whose treatment
remains challenging. There exist effective pharmacological therapies for chronic
constipation, however, many patients do not well respond to current medications. Evidence
suggests that disturbance in the gastrointestinal microbiota may be implicated in chronic
constipation. Although, E.coli Nissle 1917 (Mutaflor®) has been used for chronic
constipation, there are limited data regarding the efficacy of E.coli Nissle 1917 (Mutaflor®)
in these patients. Therefore, this study aimed to investigate the efficacy of E.coli Nissle
1917 (Mutaflor®) in patients with chronic constipation.