The Efficacy of Intravenous Acetaminophen During Perioperative Neurosurgery Period
Status:
Completed
Trial end date:
2017-01-20
Target enrollment:
Participant gender:
Summary
This is a prospective randomized double blinded trial study involving 128 patients undergoing
any craniotomy procedure at Evanston Hospital. The patients will be randomized by the sealed
envelope technique. The anesthesiologist and nurses who will be administering the placebo or
intravenous acetaminophen will be blinded to the group in which patients are assigned.
The following general perioperative data will be recorded: patient information/preoperative
data, procedural information, postoperative information, and overall satisfaction of pain
management at 24 hours after surgery.
Based on a pilot study (N-20) we expect that 25% of the placebo treated patients will require
no opioids in the first 24 hour postoperative period. With the use of intravenous
acetaminophen, it is hypothesized that the number of patients that do not require opioids in
the first 24 hours after surgery will double.
Phase:
Phase 4
Details
Lead Sponsor:
NorthShore University HealthSystem NorthShore University HealthSystem Research Institute