The Efficacy of Intermittent Versus Daily Oral Iron Supplementation in Anaemic Pregnant Women.

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

In this study intermittent dosage of iron supplementation three times a week will be compared to daily dosage in anaemic pregnant women due to iron deficiency.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Martini Hospital Groningen
• Collaborator: dr. J.M. Munster, gynaecologist, principal investigator
• Treatments: Ferrous fumarate

Criteria

Inclusion Criteria:

• Pregnant women of 18 years and older

• Iron deficiency anaemia (defined as: Anaemia (haemoglobin lower than cut-off value) AND mean corpuscular volume (MCV) 70-85 fl OR ferritin <30ug/L) OR mean corpuscular volume (MCV) < 70fl / hemoglobinopathy is ruled out.

• Adequate mental health

• Good command of the Dutch language

• No participation in other research with medication

• Informed consent

Exclusion Criteria:

• Start of iron supplementation at pregnancy duration > 37 weeks (because of the limited time to achieve an increase in haemoglobin).

• History of bariatric surgery, inflammatory bowel disease, coeliac disease or Helicobacter pylori infection (because of malabsorption of iron).

• Patients who received blood transfusion or parental iron supplementation during the 3 months prior to screening (because of the effect on the haemoglobin level).

• Patients with significant bleeding, blood donation or surgery during pregnancy (because of the effect on the haemoglobin level).

• Allergy for iron.

• Anaemia of other cause, such as a hemoglobinopathy.