The Efficacy of Imipramine in Treatment of Refractory Functional Dyspepsia
Status:
Completed
Trial end date:
2010-08-01
Target enrollment:
Participant gender:
Summary
The aim of this study is evaluate the efficacy of Imipramine, a tricyclic antidepressant, in
treatment of functional dyspepsia. This is a double blind randomised placebo controlled trial
in which consecutive patients with diagnosis of functional dyspepsia will be studied. After
exclusion of organic cause of dyspepsia by endoscopy, these patients will be randomly
assigned to either imipramine or placebo. All the patients will enter an additional 4 weeks
of drug withdrawal phase after the initial 12 weeks of study drug treatment. They will be
evaluated for treatment response, which is defined as satisfactory relief of dyspeptic
symptoms at the end of 12-week treatment.