Overview

The Efficacy of Denosumab in Decreasing Periprosthetic Bone Loss in Patients With Total Knee Arthroplasty

Status:
Completed
Trial end date:
2015-06-01
Target enrollment:
0
Participant gender:
All
Summary
This study evaluates the effect of Denosumab in decreasing the periprosthetic bone resorption after Total Knee Arthroplasty compared to placebo in 60 patients (30 placebo and 30 Denosumab) within a year after surgery.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
FundaciĆ³ Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Treatments:
Denosumab
Criteria
Inclusion Criteria:

- Patients with Knee Osteoarthritis treated with Total Knee Arthroplasty

Exclusion Criteria:

- Patients allergies to Denosumab

- Patients with previous Osteoporosis treatment

- Patients with renal failure

- Patients with previous Bisphosphonate treatment for more than 5 years