The Efficacy of Cimetidin for Acute - Extrinsic Atopic Dermatitis Treated With Standard Therapy
Status:
Unknown status
Trial end date:
2020-06-30
Target enrollment:
Participant gender:
Summary
Extrinsic - atopic dermatitis is characterized by increased of IgE serum levels. Acute
extrinsic - atopic dermatitis is a type 1 hypersensitivity that involve various inflammatory
mediator including Interleukin-4, Interleukin-12, and Interferon-Ɣ. Recent treatment of
atopic dermatitis mainly focused on reducing the inflammation through topical and systemic
regiments. However, no systemic medication could control the atopic dermatitis remission yet,
and the current immunosuppressive agent used may cause many side effects if administered on a
long term basis.
In the future, treatment of atopic dermatitis were specifically targeted to inhibit the role
of Th2. Cimetidine is H2 receptor antihistamine that has been widely used as gastrointestinal
medication for a long time. Cimetidine could modulate the immune system by activating the Th1
and lowering the Th2 activity, and lowering the IgE levels thus reducing the severity of
atopic dermatitis.