The Efficacy of Botulinum Toxin in Disabling Multiple Sclerosis (MS) Tremor
Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
The incidence of tremor in Multiple Sclerosis (MS) has been estimated to affect up to 2/3rds
of patients. Over half of the tremors involve the upper limb and frequently lead to further
disability. Medical treatment of MS tremor is generally unrewarding, although carbamazepine,
clonazepam, glutethimide, hyoscine, isoniazid, ondansetron, primidone, and
tetrahydrocannabinol have been reported to have some beneficial effect but published evidence
of effectiveness is very limited. The investigators' experience to date suggests that many of
the upper limb tremors may potentially be responsive to Botulinum toxin injection therapy.
Aims:
1. The investigators aim to determine the efficacy of commonly used doses of BOTOX on the
patients with symptomatic unilateral or bilateral arm tremor due to MS; and any side effects
associated with this treatment.
Phase:
Phase 3
Details
Lead Sponsor:
Melbourne Health
Collaborator:
Eastern Health
Treatments:
abobotulinumtoxinA Botulinum Toxins Botulinum Toxins, Type A incobotulinumtoxinA onabotulinumtoxinA