The Efficacy of Asacol (Mesalazine) Suppository on the Treatment of Diarrhea-Induced Acute Fissure
Status:
Completed
Trial end date:
2021-01-10
Target enrollment:
Participant gender:
Summary
Anal fissure define as a superficial tearing in mucosa on the anoderm surface distal to
dentate line . The most important factor is hard stool passing with trauma to anal mucosa.
But, diarrhea diarrhea has been another important etiology that happen after some conditions
like gastroenteritis, laxative over use, during chemotherapy, and ulcerative colitis
exacerbation . In these conditions, it seems the change of stool PH maybe the main reason of
inflammation and ulcer in acute phase.
The treatment of acute is medical management with change in bowel habits and conservative
therapy such as local lubricant, local vasodilator, and warm sitz bath to improve blood
supply and wound healing.
This research clinical trial is designed to show the effect of Asacol suppository in the
management of acute fissure due to diarrhea. The hypothesis of this research clinical trial
has been referred to the cause of acute fissure ulcer because of diarrhea.