The Efficacy of Alpha-blockers for Expulsion of Distal Ureteral Stones
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Most of the patients suffering from renal colic have a distal ureterolithiasis. It had been
demonstrated that α adrenoreceptors antagonists, given to patients suffering from renal
colic, due to distal ureterolithiasis, had increased the frequency of stone expulsion rate ,
reduced the time to expulsion and reduced analgesics consumption.Most of the studies
evaluated the efficacy of Tamsulosin, which is a selective α 1A and α 1D adrenoreceptors
antagonist.(The lower intramural portion of the ureter, where it passes through the detrusor
muscle contains mostly α 1D and α 1A adrenergic receptors)
Only one study these days describes the use of Alfuzosin, which is an α adrenergic receptor
blocker and not selective for any α 1 adrenergic receptor, for expulsion of distal ureteric
stones.Alfuzosin is a drug with a proven efficacy and considered uroselective with high
specificity and sensitivity, for the treatment of BPH. There was no significant difference in
efficacy between the two α blockers (Alfuzosin vs. Tamsulosin) concerning symptoms relief or
flow improvement.
The objective of this study is to compare patient who would receive the standard treatment
for distal ureterolithiasis (analgesics, Rowatinex) to patients who would receive also a non
selective α blocker (Alfuzosin) or a selective α blocker (Tamsulosin). This in order to
evaluate the efficacy of treatment with α blockers for expulsion of distal ureterolithiasis.