The Efficacy and Safety of Sirolimus for Plastic Bronchitis

• Status: Unknown status
• Trial end date: 2020-05-05
• Target enrollment: 0
• Participant gender: All

Summary

There is no confirmed drug therapy for plastic bronchitis. The study wish to test the effectiveness and safety of sirolimus (rapamycin) in patients with lymphatic plastic bronchitis.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking Union Medical College Hospital
• Collaborator: North-China Pharmaceutical Company, China
• Treatments: Everolimus; Sirolimus

Criteria

Inclusion Criteria:

• plastic bronchitis

• pulmonary lymphatic perfusion syndrome demonstrated on 68Ga-NEB positron emission tomography (PET)

Exclusion Criteria:

• Pregnancy and breastfeeding

• Severe cardiovascular, hepatic and renal dysfunction

• allergy to sirolimus or 68Ga-NEB