The Effects of a Prostaglandin Inhibitor on Ovulation and the Menstrual Cycle

• Status: Completed
• Trial end date: 2008-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

The investigators propose to test the hypothesis that the use of a prostaglandin inhibitor will result in premature luteolysis (ovulation failure) in women.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Oregon Health and Science University
• Collaborator: Society of Family Planning
• Treatments: Celecoxib; Prostaglandin Antagonists

Criteria

Inclusion Criteria:

• Age 18-35

• Normal menstrual periods (24-35 days)

• Good general health

• Willing to use a non-hormonal form of contraception for the entire study (Acceptable forms of contraception include condoms, spermicide, sexual contact with a sterilized partner, subject is surgically sterile, same-sex partner, Copper IUD and abstinence)

• Willing and able to return to clinic for bi-weekly blood tests

Exclusion Criteria:

• Pregnant or breast feeding

• Polycystic ovarian disease

• Gastrointestinal conditions (i.e.gastric ulcer)

• Currently using birth control

• Known allergy to aspirin, non-steroidal anti-inflammatory drugs (NSAIDS) or Sulfa-drugs

• Diabetes

• Cardiac disease or hypertension

• Moderate to severe heartburn (GERD)

• Obesity (BMI greater than 30)