The Effects of Using Different Anesthetics on the Prognosis of Primary Tumors and Its Mechanism of Action
Status:
Recruiting
Trial end date:
2026-07-01
Target enrollment:
Participant gender:
Summary
1. Eligible participants were assessed prior to anesthesia. After the patient is admitted
to the hospital, the subject's consent form is explained, and the consent form must be
signed before the operation.
2. This is a two-arm, parallel-group randomized clinical trial.In the preoperative waiting
area, the patients are randomly assigned and divided into two groups according to the
allocation sequence table (corresponding to 1:1 randomization) generated by the
computer. The propofol group was both induced and maintained at an effect-site
concentration (Ce) of 2.0-4.0 mcg/mL by a target-controlled infusion (TCI) system. The
sevoflurane group was maintained via sevoflurane vaporizer between 1% and 3% (target
minimum alveolar concentration of 0.7-1.3). During the operation, the dose of anesthetic
drugs (propofol/fentanyl /remifentanil and sevoflurane/cisatracurium/rocuronium) are
adjusted to maintain the mean arterial pressure and heartbeat fluctuations within 20% of
the baseline value and Entropy (or BIS) value at 40-60in both groups. The following
patient data were recorded, the type of anesthesia, sex, age at the time of surgery,
preoperative Karnofsky performance status (KPS) score and functional capacity, the
postoperative complications within 30 days (according Clavien-Dindo classification), ASA
physical status scores, tumor marker ,tumor size, intraoperative blood loss/transfusion,
duration of surgery, duration of anesthesia, total opioid (remifentanil/fentanyl) use,
postoperative radiation therapy, postoperative chemotherapy, postoperative concurrent
chemoradiotherapy, the presence of disease progression, and 6-month, 1-year, 3-year and
5-year overall survival and Karnofsky performance status score were recorded.
Phase:
Phase 4
Details
Lead Sponsor:
Kaohsiung Medical University Chung-Ho Memorial Hospital