The Effects of Two Different Intravenous Lipid Emulsions on the Outcomes of Preterm Infants With Sepsis
Status:
Completed
Trial end date:
2017-02-01
Target enrollment:
Participant gender:
Summary
Introduction and objectives: Lipid emulsions play an important role in parenteral nutrition
in preterm infants. We aim to evaluate the effect of two different intravenous lipid
emulsions on the outcomes of neonatal sepsis in preterm infants.
Methods: A randomized controlled trial is conducted in the Neonatal Care Unit of Mansoura
University Children's Hospital, Egypt. Forty preterm infants with clinically suspected sepsis
are enrolled and assigned randomly into one of two groups, one receive MOFS lipid emulsion
(MOFS group) and the other receive pure soyabean oil-based emulsion (S group). Clinical and
epidemiological data are collected. Assessment is done on 1st day and 7th day post
randomization including growth parameters, complete blood count, C-reactive protein, random
blood glucose, serum creatinine, serum triglyceride, soluble intercellular adhesion molecule
1 (sICAM-1) and leukocyte integrin β2. Between-groups and within-group differences will be
analyzed statistically.