The Effects of Statin on Postoperative Renal Function in Valvular Heart Surgery: a Randomized, Placebo-controlled Study

• Status: Completed
• Trial end date: 2015-08-21
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to examine the association between preoperative statin treatment and the incidence of postoperative acute kidney injury(AKI) in patients undergoing valvular heart surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University

Criteria

Inclusion Criteria:

• patients over the age of 20 scheduled for valvular heart surgery

Exclusion Criteria:

1. Current statin use

2. Left ventricular ejection fraction < 30%

3. Preexisting congestive heart failure

4. Severe coronary artery disease

5. Hemodynamically unstable arrhythmia

6. Cardiogenic shock during perioperative period

7. Ventricular assist device

8. Severe renal dysfunction (eGFR < 15 ml/min per 1.73 m2)

9. History of liver disease or elevated serum transaminases

10. History of rhabdomyolysis or elevated creatinine kinase