The Effects of Spinal Anesthesia on ED50 and BIS50 of Etomidate for the Loss of Consciousness

• Status: Completed
• Trial end date: 2017-07-15
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to investigate the effect of spinal anesthesia on ED50 and BIS50 of etomidate for the loss of consciousness (LOC) by using up-and-down method.The hypothesis was that spinal anesthesia could significantly reduce the etomidate bolus dose for the LOC and could also achieve hemodynamic stability during anesthesia induction.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: General Hospital of Ningxia Medical University
• Treatments: Anesthetics; Etomidate

Criteria

Inclusion Criteria:

• ASA physical status I-II

• Body mass index (BMI) between 18.0 and 24.5 kg/m2

• Undergoing short elective laparotomy procedures, hysteroscopic and vaginal operation

Exclusion Criteria:

• Contraindication to spinal anesthesia

• Hearing loss

• History of cardiovascular disease, psychiatric and central nervous system diseases

• Hepatic or renal dysfunction

• Severe diabetes or hyperkalemia

• History of drug and alcohol abuse

• An allergy to amide local anesthetics or etomidate

• Adrenocortical hypofunction