Overview

The Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease

Status:
Completed

Trial end date:
2017-06-01

Target enrollment:
0

Participant gender:
All

Summary

Objectives: The purpose of this study was to investigate the effects of high-frequency repetitive Transcranial Magnetic Stimulation (rTMS) in Alzheimer's Disease (AD). Methods: Twenty-seven AD patients aged ≥60 years were included in the study and divided into 3 groups (rTMS, Aerobic Exercise (AE) and control). All groups received pharmacological treatment. rTMS group (n=10) received 20 Hz rTMS treatment on bilateral dorsolateral prefrontal cortex, 5 days a week over 2 weeks, and AE group (n=10) received the moderate-intensity aerobic exercise for 50 min sessions, 5 days a week over 2 weeks. Control group (n=10) was only treated pharmacologically. Neuropsychiatric and behavioral status, cognition, balance, functional mobility, and quality of life, and functional brain changes were evaluated before and after the treatment.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Istanbul Medipol University Hospital

Treatments:

Cholinesterase Inhibitors
Memantine

Criteria

Inclusion Criteria:

- having clinical AD diagnosis according to the NINCDS-ADRDA (National Institute of
Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related
Disorders Association) criteria

- being 60 years and older

- having Clinical Dementia Rating Scale (CDR) scores 1 or 2

- living independently

Exclusion Criteria:

- not being able to walk independently,

- having physical disabilities,

- having a history of alcohol / substance abuse,

- having head trauma

- having epileptic seizures