The Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease
Status:
Completed
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
Objectives: The purpose of this study was to investigate the effects of high-frequency
repetitive Transcranial Magnetic Stimulation (rTMS) in Alzheimer's Disease (AD).
Methods: Twenty-seven AD patients aged ≥60 years were included in the study and divided into
3 groups (rTMS, Aerobic Exercise (AE) and control). All groups received pharmacological
treatment. rTMS group (n=10) received 20 Hz rTMS treatment on bilateral dorsolateral
prefrontal cortex, 5 days a week over 2 weeks, and AE group (n=10) received the
moderate-intensity aerobic exercise for 50 min sessions, 5 days a week over 2 weeks. Control
group (n=10) was only treated pharmacologically. Neuropsychiatric and behavioral status,
cognition, balance, functional mobility, and quality of life, and functional brain changes
were evaluated before and after the treatment.