The Effects of Reducing Stomach Acid on Post-tonsillectomy Pain

• Status: Terminated
• Trial end date: 2011-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This study was designed to determine whether post-operative pain following a tonsillectomy can be reduced by adding an antacid-like medication to the medications taken after surgery. It is hypothesized that even a small amount of stomach acid backing up and entering the mouth can increase post-tonsillectomy pain. Therefore, the use of an antacid-like medication should help to decrease pain and reduce the amount of narcotic medication required for pain control.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Boston Children's Hospital; Boston Children’s Hospital
• Treatments: Dexlansoprazole; Lansoprazole

Criteria

Inclusion Criteria:

• All healthy children ages 5-18 years scheduled for tonsillectomy and /or adenotonsillectomy for sleep disturbance secondary to airway obstruction at Children's Hospital Boston

Exclusion Criteria:

• Patients on any medications other than the study drug (Lansoprazole or placebo), Amoxicillin®, and acetaminophen with or without codeine

• An underlying medical condition which would necessitate an alteration in the anesthetic regimen

• Patients allergic to any of the medications in the protocol

• History of chronic tonsillitis

• History of chronic pain conditions

• History of active gastro-esophageal reflux disease

• Surgery in addition to tonsillectomy/adenotonsillectomy (except for myringotomy)

• Cognitive/developmental disorders

• Inability to use a self-report pain scale