Overview

The Effects of RVX000222 on Glucose Metabolism in Individuals With Pre-diabetes

Status:
Completed
Trial end date:
2014-03-01
Target enrollment:
0
Participant gender:
Male
Summary
This study builds on data that high-density lipoprotein (HDL) has a number of potentially beneficial effects including directly modulating glucose metabolism through multiple mechanisms. The primary objective of this study is to determine the effects of RVX000222 on postprandial plasma glucose in male individuals with impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), during a frequently sampled oral glucose tolerance test (OGTT).
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Resverlogix Corp
Collaborators:
Baker Heart and Diabetes Institute
Baker IDI Heart and Diabetes Institute
Nucleus Network Ltd
Criteria
Inclusion Criteria:

- Males aged 18-70 years, inclusive

- Body mass index (BMI): 25-40 kg/m2

- HDL cholesterol plasma levels: ≤1.4 mmol/L

- Pre-diabetes: Either impaired fasting glucose (IFG; 6.1-6.9mmol/L) or impaired glucose
tolerance (IGT; 2 hour OGTT glucose 7.8-11.0mmol/L, WHO classification) as measured at
Visit 1

- No current use or need for prescription or over-the-counter medication within four
days of Visit 1

- Have given signed informed consent to participate in the study

Exclusion Criteria:

- Identification of any other medical condition requiring immediate therapeutic
intervention

- Has received any over-the-counter medication including vitamins, herbal, or dietary
supplements within four days of Visit 1 unless prior approval from the Investigator

- Tobacco use within six months of Visit 1 (including cigarettes, pipes, chewing
tobacco)

- Elective surgery requiring general anaesthesia during the course of the study

- Clinically significant heart disease at Visit 1

- Clinically significant abnormal ECG at Visit 1

- Evidence of renal impairment defined as serum creatinine >1.5 mg/dL (133 μmol/L) or
creatinine clearance of <60 mL/min

- History of hypertension or supine SBP >160mmHg or DBP >95mmHg as measured at Visit 1

- Evidence of type 2 diabetes (fasting plasma glucose ≥7.0mmol/L; 2 hour OGTT glucose
≥11.1mmol/L)

- Evidence of liver disease defined as aspartate aminotransferase (AST), alanine
aminotransferase (ALT) or total bilirubin >1.5 x upper limit of normal (ULN) at Visit
1

- History of malignancy within past 5 years

- History or evidence of drug or alcohol abuse within 12 months of Visit 1

- Use of other investigational drugs and/or devices at the time of enrolment, or within
30 days of Visit 1

- History of non-compliance to medical regimens or unwillingness to comply with the
study protocol

- Any condition that in the opinion of the Investigators would confound the evaluation
and interpretation of the data

- Persons directly involved in the execution of the protocol