The Effects of Propranolol on Fear of Tooth or Molar Extraction

• Status: Completed
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Randomized, placebo-controlled, double-blind, parallel group clinical trial evaluating the anxiolytic effects of propranolol on fear of wisdom tooth removal. It is hypothesized that, compared to placebo, perioperative oral propranolol reduces dental trait anxiety at 1 month follow-up after wisdom tooth removal.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
• Treatments: Propranolol

Criteria

Inclusion criteria

1. Signed written informed consent

2. ≥ 18 Years of age on entry to the study

3. Self-reported high to extreme fear of tooth or molar removal

4. Dutch or English-speaking

Exclusion criteria

1. Asthma or other obstructive pulmonary disease

2. Cardiac failure

3. Cardiac arrhythmia

4. Renal failure

5. Insulin-dependent diabetes mellitus

6. Pregnant or breast-feeding

7. Current use of another ß-adrenoreceptor antagonist

8. Current use of anxiolytic or antidepressant medication

9. Currently in psychotherapy for dental anxiety

10. Systolic blood pressure < 100 mmHg