The Effects of Perioperative Dexmedetomidine Administration on Immune Suppression and Outcomes in Patients With Uterine Cancer Undergoing Radical Resection

• Status: Completed
• Trial end date: 2018-10-24
• Target enrollment: 0
• Participant gender: Female

Summary

Surgical stress and anesthesia may cause immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. Dexmedetomidine has sympatholytic effect and preserves NK cell function. This study investigate the effect of dexmedetomidine on immune suppression and postoperative outcomes in patients undergoing uterine cancer resection.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• patient between 20 and 70 of age with ASA physical status Ⅰ-Ⅲ

• patient scheduled for uterine cancer surgery

Exclusion Criteria:

• ASA physical status Ⅳ

• severe hepatorenal disease

• infection

• metastasis to other organ

• problem with communication