The Effects of Peri-operative Pregabalin Administration on Post-operative Analgesia in Patients Undergoing Coronary Bypass Grafting

• Status: Unknown status
• Trial end date: 2011-06-01
• Target enrollment: 0
• Participant gender: All

Summary

We hypothesize that the perioperative administration of pregabalin will significantly decrease pain scores and post-operative opioid requirements for patients undergoing coronary artery bypass grafting, and reduces the incidence of opioid-induced side effects such as respiratory depression. This may reduce ICU admission and possibly abbreviate length of hospital stay.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Manitoba
• Treatments: Pregabalin

Criteria

Inclusion Criteria

• Patients whom are able and willing to provide written informed consent.

• Male and female 18-70 years of age.

• Patients whom are undergoing isolated coronary artery bypass grafting through a midline sternotomy for the treatment of ischemic heart disease.

Exclusion criteria

• Patients undergoing cardiac surgery for valvular or pericardial surgery.

• Patients with a documented ejection fraction of less than 50%.

• Patients with known chronic renal insufficiency and a calculated creatinine clearance of < 60mL/min.

• Patients with known sensitivity to the study drugs.

• Patients with documented pre-existing chronic pain.

• Patients with seizure disorders.

• Patients whom are taking pregabalin or gabapentin

• Patients on chronic neuroleptic medications for control of psychiatric disorders as to avoid possible drug interactions and to avoid modulation of any pain states by such medications.

• Patients whom are taking tricyclic antidepressants or serotonin and norepinephrine re-uptake inhibitors(SNRI) will be excluded because of the effect of these drugs on neuropathic pain.

• Patients greater than 70 years of age will also be excluded because of their increased risk of side-effects and perioperative confusion.

• Pregnant or breast feeding females