The Effects of PXR Activation on Hepatic Fat Content
Status:
Completed
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
This study investigates the effects of pregnane X receptor (PXR) activation on hepatic fat
content in healthy volunteers. Rifampicin (an antibiotic and also an efficient PXR activator)
and placebo will be given for a week to volunteers. Hepatic fat content is measured with
magnetic resonance imaging and blood samples are collected at the end of each study arm. The
investigators' hypothesis is that rifampicin causes accumulation of fat to the liver.