The Effects of Nifedipine and Metoprolol on Blood Pressure Variability in Northern Chinese
Status:
Unknown status
Trial end date:
2018-10-01
Target enrollment:
Participant gender:
Summary
Hypertension is one of the most common cardiovascular diseases, which is a major risk factor
for stroke and cardiovascular events. Traditionally, cardiovascular risk stratification in
hypertensive patients was based on the average blood pressure (BP) measured in the clinic.
Accumulated data has shown that target-organ damage is related not only to 24-h mean
intra-arterial BP, but also to BP variability (BPV) in subjects with essential hypertension.
Growing evidence demonstrated that BPV has considerable prognostic value for all-cause
mortality and cardiovascular outcomes, independent of average BP.
At present, the normal range of BPV is not very clear. There are many studies about the
effects of different kinds of drugs on blood pressure, but the clinical researches about the
impacts of antihypertensive drugs on BPV are limited, and the conclusion is still
controversial.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
First Affiliated Hospital of Harbin Medical University