The Effects of Nasal Airflow on Upper Airway Dilator Muscles During Sleep

• Status: Unknown status
• Trial end date: 2018-05-12
• Target enrollment: 0
• Participant gender: All

Summary

Obstructive sleep apnea (OSA) is an increasingly prevalent disorder characterized by repeated upper airway collapse during sleep, resulting in oxygen desaturation and frequent arousals. The etiology of OSA remains unclear.

Many studies indicates an association between nasal obstruction and apnea. However,the precise nature of this relationship is far from clear and the importance of resistance to nasal airflow in the pathogenesis of airway collapse in OSA patients remains contentious.

In this study, investigators perform 4 different ways to change subjective or objective patency of nasal cavity and observe the effects of the nasal airflow on nocturnal breathing, sleep,and upper airway muscles in OSA patients.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Beijing Tongren Hospital
• Treatments: Menthol; Oxymetazoline; Phenylephrine

Criteria

Inclusion Criteria:

• OSA patients (apnea/hyponea index >5/h）with chronic nasal congestion

Exclusion Criteria:

• Upper airway surgery;

• Current treatment with nasal topical steroids or decongestants;

• Internal medical diseases or psychiatric disorders that interferd with sleep.