The Effects of Mild Sedation on Motor Function Networks in Patients With Brian Gliomas
Status:
Recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
It has been shown through functional MRI (Magnetic Resonance Imaging) that patients with
gliomas in eloquent areas have compensated neurological function by virtue of brain
post-injury reorganization. Our previous clinical research found that mild sedation could
induce and/or exacerbate neurological deficits, especially in limb motor and ataxia function,
in these patients presumably by impairing functional compensation,. Nevertheless it is still
very unclear how mild sedation affects sensorimotor networks in brains where reorganization
may be present. Since eloquent area glioma patients are frequently subjected to sedation,
anesthetics, and neurological examinations perioperatively, it is important to investigate
how mild sedation interacts with motor network reorganization and functional compensation.
Our research in patients with eloquent area gliomas will utilize neurological evaluations and
multimodal MRI to explore the changes in brain upper limb' motor network reorganization after
mild sedation by different sedatives-anesthetics. The neurological evaluations include
sensorimotor function scale and testing tool. Multimodal MRI consists of 3-dimentional
structure, blood oxygen-level dependent for cortical activation and diffusion tensor imaging
for subcortical conduction. The data from the clinical testing and functional MRI will be
processed and analyzed along with other relevant clinical information. This research will
answer the question of how mild sedation affects upper limb motor function networks in brains
with eloquent area gliomas. This new information will help optimize perioperative anesthetic
and sedative choice for patients with eloquent area gliomas.