The Effects of Metformin on Self-selected Exercise Intensity, Physical Fitness and Exercise-induced AMPK-activation

• Status: Completed
• Trial end date: 2017-07-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to evaluate the potential interaction between metformin and exercise in order to optimize clinical guidelines for treatment of T2D.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Rigshospitalet, Denmark
• Collaborator: University of Copenhagen
• Treatments: Metformin

Criteria

Inclusion Criteria:

• male

• HbA1c < 39 mmol/l

• BMI < 25

• structured physical activity < = 150 min/week

• apparently healthy

Exclusion Criteria:

• smoking

• daily pharmaceutical treatment

• contraindication to increased levels of physical activity

• ALAT/ASAT elevated 3 times above upper normal values

• renal insufficiency (eGFR < 60 ml/min)

• prior history of lactic acidosis