The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users

• Status: Completed
• Trial end date: 2016-07-11
• Target enrollment: 0
• Participant gender: All

Summary

This study will help determine if menthol administered by inhalation via electronic cigarettes (e-cigarette) changes the reinforcing effects of pure nicotine administered intravenously in cigarette smokers who smoke mentholated or non-mentholated cigarettes.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Yale University
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Menthol; Nicotine

Criteria

Inclusion Criteria:

• Female and male smokers, aged 18 to 30 years;

• History of smoking for the past 12 months, at least one cigarette per day; smoking status is verified with urinary cotinine levels above 10 ng/ml;

• Not seeking treatment for nicotine dependence at the time of study entry;

• In good health as verified by medical history, screening examination, and screening laboratory tests;

• For women, not pregnant as determined by pregnancy screening, nor breast feeding, and using acceptable birth control methods.

Exclusion Criteria:

• History of major medical illnesses that the physician investigator deems as contraindicated for the patient to be in the study

• Regular use of psychotropic medication (antidepressants, antipsychotics, or anxiolytics);

• A psychiatric diagnosis and / or treatment for Axis I disorders including major depression, bipolar affective disorder, schizophrenia or panic disorder in the past month

• Abuse of alcohol or any other recreational or prescription drugs in the past 30 days.

• Any allergy to propylene glycol or menthol.