The Effects of Maxipost (BMS 204352) on Cerebral Hemodynamic and Headache in Healthy Volunteers and Migraine Patients
Status:
Completed
Trial end date:
2020-02-29
Target enrollment:
Participant gender:
Summary
It is not previously investigated whether, there is a correlation between potassium channels
and migraine, so it is unclear whether, this signaling pathway through potassium channels has
an impact on migraine pathophysiology.
Maxipost (BMS 204352) is a vasoactive molecule that causes vasodilation via the big calcium
dependent potassium (BKCa) channel signaling pathway. Maxipost decreases the blood pressure
and maxipost infusion causes headache in healthy volunteers. A possible coherence between
maxipost and headache/migraine in healthy volunteers and migraine patients is yet to be
investigated.
The present study aims to clarify a possible coherence between maxipost and headache/migraine
and it will help to shed light on the importance of potassium channels in migraine. In
general, the study will contribute to a greater understanding of migraine pathogenesis and
possibly lead to development of specific migraine treatment.