The Effects of Levcromakalim in Patients With Cluster Headache
Status:
Recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
Cluster headache is a primary headache disorder characterized by attacks of unilateral
headache of short duration and severe pain intensity. There is an unmet need to understand
the underlying disease mechanisms that will ultimately lead to the development of
disease-specific medicines. Until now, it has been suggested that the calcitonin gene-related
peptide (CGRP) plays a major role in the initiation of a cluster headache attack, possibly
involving the ATP-sensitive potassium channels. The current study aims to determine whether
the opening of ATP-sensitive potassium channels triggers cluster headache attacks in patients
with cluster headache.