The Effects of Interferon-gamma on Sepsis-induced Immunoparalysis
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
The primary aim of this study is to assess the effects of adjunctive therapy with Interferon
(IFN)-gamma on immune function in patients with septic shock in a placebo-controlled manner.
Moreover, the investigators want to evaluate new markers that could be used to identify
patients with immunoparalysis, and to monitor the patient's immunological response to IFN-γ.
In addition, mechanistic studies will be performed to further elucidate mechanisms (such as
epigenetic modifications) behind immunoparalysis and the effects of IFN-γ on these
mechanisms. With use of the results the investigators will obtain in this pilot study, the
investigators will conduct a large multicentre clinical trial with IFN-γ.