The Effects of Intensive Insulin on Somatic and Visceral Protein Turnover in Acute Kidney Injury (AKI)
Status:
Withdrawn
Trial end date:
2008-11-01
Target enrollment:
Participant gender:
Summary
We propose to determine the acute metabolic effects of intensive insulin therapy when
administered to AKI patients with a particular focus on its effects on protein metabolism. We
hypothesize that the degree of insulin resistance correlates with protein catabolism in
critically ill patients with AKI, and that intensive insulin therapy will result in
substantial reductions in both whole-body and skeletal muscle protein breakdown thereby
improving overall protein balance. We also hypothesize that this therapy will have favorable
effects on the inflammatory and oxidative stress profile of patients with AKI. The metabolic
response to these interventions will be assessed through stable isotope infusion techniques,
allowing for the most precise assessment of protein and energy homeostasis.
Phase:
Phase 2
Details
Lead Sponsor:
Vanderbilt University Vanderbilt University Medical Center