The Effects of IV vs Oral Dexamethasone on Postoperative Nausea, Vomiting, and Pain

• Status: Recruiting
• Trial end date: 2021-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The hypothesis being tested in this study is that perioperative oral administration of dexamethasone, when compared to intravenous (IV) administration, offers a similar reduction in postoperative nausea and vomiting (PONV), and reduction in postoperative pain in pediatric patients undergoing tonsillectomy with or without adenoidectomy and/or tympanostomy tube placement. The specific aim of this study is to demonstrate non-inferiority of oral dexamethasone when compared to IV dexamethasone, given that there is currently a severe, sudden, and world-wide shortage of IV dexamethasone given its recent use in treating patients with covid19 disease.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Colorado, Denver
• Treatments: Dexamethasone

Criteria

Inclusion Criteria:

• 3-7 years of age

• tonsillectomy with or without adenoidectomy and tympanostomy tube placement

Exclusion Criteria:

• Subjects receiving one week before surgery:

•-antiemetics

• steroids

• anti-histaminic

• psychoactive drugs