The Effects of Growth Hormone (GH) on Lipid Depots
Status:
Completed
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
This study aims at investigating the effect of growth hormone on lipid-content of muscle and
liver as well as visceral fat mass in relation to insulin sensitivity.
In addition, hormonal regulation and free fatty availability is assessed during a physical
exercise at 50-60% VO2max.
Finally, the value of physical exercise in diagnosing growth hormone deficiency is
investigated.
Hypothesis: 1) Lipid content of muscle and liver change with physical exercise and exercise
capacity and free fatty availability will influence these changes. 2)Growth hormone
replacement therapy will predominantly reduce visceral fat mass and increase free fatty
availability.
3)Free fatty availability during exercise will be reduced in growth hormone deficient
patients 4)Physical exercise may be an alternative way to diagnose growth hormone deficiency