The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction
Status:
Not yet recruiting
Trial end date:
2025-03-31
Target enrollment:
Participant gender:
Summary
Caloric restriction (and RYGB) improves insulin action and lowers fasting glucose, glucagon
and EGP, without changes in postprandial EGP and glucagon concentrations. Caloric restriction
also improves hepatic steatosis and lowers fasting AA. These changes may represent
restoration of glucagon's hepatic actions. This experiment will determine whether caloric
restriction improves glucagon's actions on hepatic amino acid, carbohydrate and lipid
metabolism in T2DM in comparison to a baseline experiment performed separately in people with
T2DM.